RBE-dose relations for neutrons and pions.
نویسندگان
چکیده
From cellular radiosensitivity parameters and theoretical particle-energy spectra in tissue, of the secondary particles from neutron and negative pion irradiations, RBE-Dose relations have been calculated. The theoretical results are compared with clinical and radiobiological data for normal tissue, tumours and cells in culture. Formulae for calculation, cellular parameters and the needed properties of equivalent 'track-segment bombardments' are given, for several mammalian cells irradiated with pions and with neutrons of several energies.
منابع مشابه
Fast-neutron radiobiology and radiotherapy.
The application of fast neutrons, negative pions or heavy ions will only provide an advantage for the radiotherapy of cancer if, in comparison with conventional radiations, e.g., X-rays, gamma rays and electrons, better depth-dose and collimation characteristics or specific radiobiological dose response relationships result in greater local control probabilities for tumours without increased fr...
متن کاملFifteen symposia on microdosimetry: implications for modern particle-beam cancer radiotherapy.
The objective of microdosimetry was, and still is, to identify physical descriptions of the initial physical processes of ionising radiation interacting with biological matter which correlate with observed radiobiological effects with a view to improve the understanding of radiobiological mechanisms and effects. The introduction of therapy with particles starting with fast neutrons followed by ...
متن کاملTrabecular bone changes induced by fast neutrons versus gamma rays in mice
Background: The trabecular bone changes in the tibia of C3H/HeN mice were measured 12 weeks after whole body irradiation with various doses of fast neutrons (0-2.4 Gy) or 137Cs-generated gamma-rays (0-6 Gy). Materials and Methods: Serum calcium, phosphorus, estradiol concentration and alkaline phosphatase activity were measured. Tibiae were anal...
متن کاملAccounting for neutron exposure in the Japanese atomic bomb survivors.
The Japanese atomic bomb survivors that were directly exposed to both γ rays and neutrons have been followed by the Radiation Effects Research Foundation (RERF). The estimation of the γ-ray risks requires some adjustment for the greater biological effect of the neutrons per unit dose. Because the small neutron doses and the predominant γ-ray doses are highly correlated, the neutron relative bio...
متن کاملNeutron relative biological effectiveness in Hiroshima and Nagasaki atomic bomb survivors: a critical review
The calculated risk of cancer in humans due to radiation exposure is based primarily on long-term follow-up studies, e.g. the life-span study (LSS) on atomic bomb (A-bomb) survivors in Hiroshima and Nagasaki. Since A-bomb radiation consists of a mixture of γ-rays and neutrons, it is essential that the relative biological effectiveness (RBE) of neutrons is adequately evaluated if a study is to s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Physics in medicine and biology
دوره 20 3 شماره
صفحات -
تاریخ انتشار 1975